Adrenergic receptor alpha 2B (α2B-adrenoceptor)
- Target Class
- GPCR
- Family
- Adrenoceptors
- Official Symbol
- ADRA2B
- Species
- Human
- Accession Number
- NM_000682.5
- Alias Names
- ADRA2B adrenergic, alpha-2B-, receptor; ADRA2L1; ADRA2RL1; ADRARL1; ALPHA2BAR; G-protein coupled receptor; adrenergic receptor alpha 2B; adrenergic, alpha-2B-, receptor; alpha-2 adrenergic receptor subtype C2; alpha-2-adrenergic receptor-like 1; alpha-2B adrenergic receptor; alpha-2B adrenoceptor; alpha-2B adrenoreceptor; alpha-2B-adrenergic receptor; alpha-2BAR; a2B
- Background
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. This intronless gene encodes the alpha2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. [provided by RefSeq, Aug 2011]
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Solution Portfolio
Related Family Members:
Adrenoceptors
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family
| Assay Readout |
Background |
Species |
Cell Line |
| β-Arrestin |
CHO-K1 |
Human |
93-0641C2 |
| KINOMEscan |
TKscan |
BROMOscan |
NHRscan |
GPCRscan |
PATHscan |
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Available |
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