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Adrenergic receptor alpha 2A (α2A-adrenoceptor)

Target Class
GPCR
Family
Adrenoceptors
Official Symbol
ADRA2A
Species
Human
Accession Number
NM_000681
Alias Names
ADRA2; ADRA2R; ADRAR; ALPHA2AAR; ZNF32; adrenergic, alpha-2A-, receptor; alpha-2 adrenergic receptor subtype C10; alpha-2-adrenergic receptor, platelet type; alpha-2A adrenergic receptor; alpha-2A adrenoceptor; alpha-2A adrenoreceptor; alpha-2AAR subtype C10; a2A
Background
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Family Members:

Adrenoceptors
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Readout Background Species Cell Line
β-Arrestin CHO-K1 Human 93-0424C2
cAMP CHO-K1 Human 95-0126C2
Assay Readout Background Species Assay Kit
cAMP CHO-K1 Human 95-0126E2CP2S
cAMP CHO-K1 Human 95-0126E2CP2M
cAMP CHO-K1 Human 95-0126E2CP2L
β-Arrestin CHO-K1 Human 93-0424E2CP0S
β-Arrestin CHO-K1 Human 93-0424E2CP0M
β-Arrestin CHO-K1 Human 93-0424E2CP0L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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