BioMAP® Diversity PLUS Panel

    Diversity PLUS consists of 12 BioMAP Systems containing early passage primary human cell types from multiple tissues that represent a broad range of human biology relevant to multiple therapeutic areas. Cells are cultured alone or as co-cultures and stimulated with a combination of factors to recapitulate the multi-component signaling networks associated with disease states. Compounds are interrogated in these systems to determine their phenotypic impact on physiologically relevant disease biology in terms of efficacy and safety.
 
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Drug Discovery Applications

  • Translational biology for drug discovery
  • Phenotypic drug discovery
  • Competitive analysis and comparison to clinical standards of care
  • Analysis of compounds with novel mechanisms of action
  • Biomarker discovery

Diversity PLUS Advantages

  • Predictive – Regulatory and feedback mechanisms
  • Reproducible – Fully automated platform
  • Efficient – Hundreds of targets and mechanisms are interrogated simultaneously
  • Powerful – Comparison of test compounds to large database
  • Meaningful – Correlation of BioMAP responses to clinical data

Learn about the Tox Alert Add-on for statistical predictions of safety and common adverse events

Diversity PLUS Panel Service

Service

  • Compound profiling (chemicals or biologics) in 12 BioMAP Systems
  • 148 readouts at 4 concentrations

Description

  • Annotation Identification and biological intrepretation of relevant BioMAP activities
  • Similarity Search Results from unsupervised search for a biologically  similar compound from the BioMAP reference database of >3000 compounds, biologics, approved drugs and experimental agents
  • Benchmarking Direct comparison of test agent to a specified reference compound from the BioMAP Database

Deliverables

  • Study Report BioMAP profile plots, annotation of activities with respect to biological significance, graphical overlays of test and reference compound profiles, results of similarity search, expert data interpretation and collaborative analysis
  • Data Report Log ratio data tables, 95% significance envelope, table of cytotoxicities, table of active readouts

Available Systems & Readouts

System ▲RelevanceCell TypeBiomarker Readout
/MphgCardiovascular Disease, Chronic Inflammation, RestenosisMacrophages + Venular endothelial cellsCCL2/MCP-1, CCL3/MIP-1 α, CD106/VCAM-1, CD40, CD62E/E-Selectin, CD69, CXCL8/IL-8, IL-1 α, M-CSF, sIL-10, SRB, SRB-Mphg
3CCardiovascular Disease, Chronic InflammationVenular endothelial cellsCCL2/MCP-1, CD106/VCAM-1, CD141/Thrombomodulin, CD142/Tissue Factor, CD54/ICAM-1, CD62E/E-Selectin, CD87/uPAR, CXCL8/IL-8, CXCL9/MIG, HLA-DR, Proliferation, SRB
4HAllergy, Asthma, AutoimmunityVenular endothelial cellsCCL2/MCP-1, CCL26/Eotaxin-3, CD106/VCAM-1, CD62P/P-Selectin, CD87/uPAR, SRB, VEGFR2
BE3CCOPD, Lung InflammationBronchial epithelial cellsCD54/ICAM-1, CD87/uPAR, CXCL10/IP-10, CXCL11/I-TAC, CXCL8/IL-8, CXCL9/MIG, EGFR, HLA-DR, IL-1 α, Keratin 8/18, MMP-1, MMP-9, PAI-I, SRB, tPA, uPA
BF4TAllergy, Asthma, Fibrosis, Lung InflammationBronchial epithelial cells + Dermal fibroblastsCCL2/MCP-1, CCL26/Eotaxin-3, CD106/VCAM-1, CD54/ICAM-1, CD90, CXCL8/IL-8, IL-1 α, Keratin 8/18, MMP-1, MMP-3, MMP-9, PAI-I, SRB, tPA, uPA
BTAllergy, Asthma, Autoimmunity, OncologyB cells + Peripheral blood mononuclear cellsB cell Proliferation, PBMC Cytotoxicity, Secreted IgG, sIL-17A, sIL-17F, sIL-2, sIL-6, sTNF-α
CASM3CCardiovascular Inflammation, RestenosisCoronary artery smooth muscle cellsCCL2/MCP-1, CD106/VCAM-1, CD141/Thrombomodulin, CD142/Tissue Factor, CD87/uPAR, CXCL8/IL-8, CXCL9/MIG, HLA-DR, IL-6, LDLR, M-CSF, PAI-I, Proliferation, Serum Amyloid A, SRB
HDF3CGFChronic Inflammation, FibrosisDermal fibroblastsCCL2/MCP-1, CD106/VCAM-1, CD54/ICAM-1, Collagen I, Collagen III, CXCL10/IP-10, CXCL11/I-TAC, CXCL8/IL-8, CXCL9/MIG, EGFR, M-CSF, MMP-1, PAI-I, Proliferation_72hr, SRB, TIMP-1, TIMP-2
KF3CTDermatitis, PsoriasisDermal fibroblasts + KeratinocytesCCL2/MCP-1, CD54/ICAM-1, CXCL10/IP-10, CXCL8/IL-8, CXCL9/MIG, IL-1 α, MMP-9, PAI-I, SRB, TIMP-2, uPA
LPSCardiovascular Disease, Chronic InflammationPeripheral blood mononuclear cells + Venular endothelial cellsCCL2/MCP-1, CD106/VCAM-1, CD141/Thrombomodulin, CD142/Tissue Factor, CD40, CD62E/E-Selectin, CD69, CXCL8/IL-8, IL-1 α, M-CSF, sPGE2, SRB, sTNF-α
MyoFChronic Inflammation, Fibrosis, Matrix Remodeling, Wound HealingLung fibroblastsbFGF, CD106/VCAM-1, Collagen I, Collagen III, Collagen IV, CXCL8/IL-8, Decorin, MMP-1, PAI-I, SRB, TIMP-1, α-SM Actin
SAgAutoimmune Disease, Chronic InflammationPeripheral blood mononuclear cells + Venular endothelial cellsCCL2/MCP-1, CD38, CD40, CD62E/E-Selectin, CD69, CXCL8/IL-8, CXCL9/MIG, PBMC Cytotoxicity, Proliferation, SRB