GPCR Screening & Profiling
Evaluate Compound Mechanism of Action or Binding Mode
The GPCR profiling service offers a collection of over 600 naturally coupled stable GPCR cell lines that enable multiple downstream signaling events to be studied in response to compound activation. Whether your focus is hit identification, selectivity profiling, or SAR optimization, these services can reduce the time and cost of GPCR drug discovery. Determine compound mechanism of action or choose a compound that shows ligand bias for development in the clinic.
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iONCscan Services for Checkpoint Receptors
Evaluate Potency, Stability, or Rank Order Drug Molecules
DiscoverX’s iONCscan services offer an expanding menu of cell-based assays that can enable screening & potency determination for new immunotherapy drugs. Assays include signaling assays for PD1, OX40, CD137 and an expanding menu of targets. Assays are specific and sensitive and most show biologically relevant responses and can be used for the discovery of small molecules or biologics.
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Nuclear Hormone Receptor Screening & Profiling
Measure NHR Translocation or Co-Activator Interaction
Nuclear Hormone Receptor Screening and Profiling Services offers over 18 different cellular assays that monitor receptor activation by either nuclear translocation or NHR co-activator interaction. These services can be used to profile compounds against a broad panel of assays for identification of new targets or determination of safety or selectivity of potential drug candidates. They can also be used to determine potency or rank ordering of potential hit or lead molecules.
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Interleukin Screening & Profiling
Discover Molecules that Activate or Inhibit Interleukin Receptors
DiscoverX offers cell-based assay services for interleukins that are highly specific and can be used to identify molecules that activate or inhibit Interleukin receptors and enable rapid development of drugs targeting immune-system disorders. These assays can be used to determine potency or rank ordering of potential hit or lead molecules.
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Discover Kinase Inhibitors with Cell-Based Assays
Identify Modulators of Receptor or Cytosolic Receptor Tyrosine Kinases
DiscoverX offers services for over 50 cell based assays for receptor tyrosine kinase and cytosolic receptor kinases. Unlike biochemical assays that commonly use a truncated version of the receptor, our cell-based kinase assays utilize wild-type, full length proteins that allow all steps in receptor activation to be monitored. This whole cell assay platform is ideal for identifying novel receptor tyrosine kinase inhibitors, allosteric modulators or antibody therapeutics.
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Pathway Screening & Profiling
Identify Molecules that Activate or Inhibit Signal Transduction Pathways
Pathway Profiling Services provides you access to a comprehensive collection of cell-based pathway indicator assays designed to detect activation or inhibition of complex signal transduction pathways in response to compound treatment. Services can be used to identify activators or inhibitors of signal transduction pathways.
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