| A-674563 |
|
|
|
Yes |
|
| AB-1010/Masitinib |
|
|
|
Yes |
|
| ABT-869/Linifanib |
|
Yes |
Yes |
Yes |
FLT3, CSF1R, VEGFR2 |
| AC220/Quizartinib |
Yes |
|
|
Yes |
FLT3 |
| AG-013736/Axitinib |
|
|
|
Yes |
|
| AMG-706/Motesanib |
|
Yes |
|
Yes |
VEGFR2, FLT1, FLT4, KIT |
| AST-487 |
|
Yes |
|
Yes |
FLT3, KIT |
| AT-7519 |
|
Yes |
|
Yes |
|
| AZD-1152HQPA/Barasertib |
|
Yes |
|
Yes |
AURKB |
| AZD-2171/Cediranib |
|
|
|
Yes |
|
| AZD-6244/ARRY-886/Selumetinib |
|
|
|
Yes |
|
| BI-2536 |
|
|
|
Yes |
|
| BIBF-1120(derivative)/Nintedanib |
|
|
|
Yes |
|
| BIBW-2992/Afatinib |
|
|
|
Yes |
|
| BIRB-796/Doramapimod |
|
Yes |
Yes |
Yes |
p38-alpha |
| BMS-345541 |
|
|
|
Yes |
|
| BMS-387032/SNS-032 |
|
Yes |
|
Yes |
CDK2 |
| BMS-540215/Brivanib |
|
|
|
Yes |
|
| CEP-701/Lestaurtinib |
Yes |
|
|
Yes |
JAK2 |
| CGP-52421 |
Yes |
|
|
|
FLT3 |
| CHIR-258/TKI-258/Dovitinib |
|
Yes |
|
Yes |
FLT3, FGFR3 |
| CHIR-265/RAF-265 |
|
Yes |
|
Yes |
BRAF, VEGFR2 |
| CI-1033/Canertinib |
|
Yes |
Yes |
Yes |
EGFR, ERBB2 |
| CI-1040 |
|
|
|
Yes |
|
| CP-690550/tofacitinib |
|
Yes |
|
Yes |
JAK3 |
| CP-724714 |
|
Yes |
|
|
ERBB2 |
| Crizotinib |
|
|
|
Yes |
|
| Dasatinib |
|
Yes |
|
Yes |
ABL1, SRC |
| EKB-569 |
|
Yes |
Yes |
|
EGFR |
| Erlotinib |
|
Yes |
Yes |
Yes |
EGFR |
| EXEL-2880/GSK1363089/Foretinib |
|
|
|
Yes |
|
| Flavopiridol/Alvocidib |
|
Yes |
Yes |
Yes |
CDK1,2,4, & CDK9 |
| GDC-0879 |
|
|
|
Yes |
BRAF |
| GDC-0941/Pictilisib |
|
|
|
Yes |
pan-PI3K |
| Gefitinib |
|
Yes |
Yes |
Yes |
EGFR |
| GSK-1838705A |
|
|
|
Yes |
|
| GSK-461364A |
|
|
|
Yes |
|
| GSK-690693 |
|
|
|
Yes |
|
| GW-2580 |
|
Yes |
|
Yes |
CSF1R |
| HKI-272/Neratinib |
|
|
|
Yes |
EGFR |
| Imatinib |
|
Yes |
Yes |
Yes |
ABL1, KIT, PDGFRB |
| INCB018424/Ruxolitinib |
|
|
|
Yes |
JAK1, JAK2 |
| JNJ-28312141 |
|
|
|
Yes |
|
| JNJ-7706621 |
|
Yes |
|
|
CDK2, CDK1, AURKB |
| Ki-20227 |
|
|
|
Yes |
|
| KW-2449 |
|
|
|
Yes |
|
| Lapatinib/GW-2016 |
|
Yes |
Yes |
Yes |
EGFR, ERBB2 |
| LY-317615/Enzastaurin |
|
|
|
Yes |
|
| LY-333531/Ruboxistaurin |
|
Yes |
Yes |
Yes |
PRKCB1 |
| MLN-120B |
|
|
|
Yes |
|
| MLN-518/Tandutinib |
Yes |
Yes |
Yes |
Yes |
FLT3, KIT |
| MLN-8054 |
|
Yes |
|
Yes |
AURKA |
| Nilotinib/AMN107 |
|
|
|
Yes |
|
| Pazopanib/GW-786034 |
|
Yes |
|
Yes |
FLT1, FLT4, PDGFRA, PDGFRB, VEGFR1, VEGFR2, VEGFR3 |
| PD-173955 |
|
|
|
Yes |
|
| PHA-665752 |
|
|
|
Yes |
|
| PI-103 |
|
Yes |
|
Yes |
PIK3CA |
| Midostaurin/PKC-412 |
Yes |
Yes |
Yes |
Yes |
FLT3, KIT |
| PP-242 |
|
|
|
Yes |
|
| PLX-4720 |
|
|
|
Yes |
|
| R406/Tamatinib |
|
|
|
Yes |
|
| R547 |
|
|
|
Yes |
|
| Roscovitine/CYC202 |
|
Yes |
Yes |
|
CDK1, CDK2, CDK5 |
| SB-202190 |
|
Yes |
Yes |
|
p38-alpha |
| SB-203580 |
|
Yes |
Yes |
Yes |
p38-alpha |
| SB-431542 |
|
Yes |
|
|
TGFBR1/ALK5, ACVR1B/ALK4 |
| SGX-523 |
|
|
|
Yes |
|
| SKI-606/Bosutinib |
|
|
|
Yes |
|
| Sorafenib/BAY-43-9006 |
Yes |
Yes |
Yes |
Yes |
VEGFR2, BRAF |
| SP600125 |
|
|
Yes |
|
JNK |
| Staurosporine |
|
Yes |
Yes |
Yes |
PRKCH, Pan-inhibitor |
| SU-14813 |
|
Yes |
|
Yes |
FLT1, FLT3, KIT, PDGFRB, VEGFR2 |
| Sunitinib/SU-11248 |
Yes |
Yes |
Yes |
Yes |
KIT, FLT3, VEGFR2 |
| TAE-684 |
|
|
|
Yes |
|
| TG-101348/Fedratinib |
|
|
|
Yes |
|
| TG-100-115 |
|
|
|
Yes |
|
| Vatalanib/PTK-787 |
|
Yes |
Yes |
Yes |
VEGFR2 |
| VX-680/MK-0457/Tozasertib |
|
Yes |
|
Yes |
AURKA, AURKB, AURKC |
| VX-745 |
|
Yes |
Yes |
Yes |
p38-alpha |
| ZD-6474/Vandetanib |
|
Yes |
Yes |
Yes |
VEGFR2, EGFR, RET |