orphanMAX Assay Panel
Listed below are the assays currently available for screening and profiling.
Data Analysis & Interpretation
Definitions
Percent Activity/Inhibition
The results for single concentration (primary screen) for tested compound(s) are reported in your study report and spreadsheets as '% Activity' or '% Inhibition' and are calculated in the following manner:
% Activity
(Agonist Mode) =
100% x
|
[ |
Mean RLU (test sample)- Mean RLU(vehicle control)
Mean MAX RLU (control ligand)- Mean RLU (vehicle control)
|
] |
test sample = client supplied compound
vehicle control = DMSO (0% activity)
control ligand = control compound (100% activity)
% Inhibition
(Antagonist mode) =
100% x
|
[ |
1- |
Mean RLU (test sample)- Mean RLU(vehicle control)
Mean MAX RLU (control ligand)- Mean RLU (vehicle control)
|
] |
test sample = client supplied compound
vehicle control = DMSO (0% activity)
EC80 control = control compound (80% activity)
Dose Response Curve (EC50/IC50)
The results for 10-point dose response curve compound/target interactions are reported in the study report and spreadsheets as EC50/IC50, which are values derived using the Hill equation:

To ensure your compounds are included in the Test Date of your choosing, submit your compounds and PO by the date indicated in the "Compounds & PO Due" column below.
2020 gpcrMAX and orphanMAX Panel Run Schedule
Panel |
Test Dates |
Compounds & PO Due |
Report & Invoicing |
gpcrMAX,
orphanMAX |
January 28 |
January 24 |
February 25 |
March 10 |
March 6 |
April 7 |
April 21 |
April 17 |
May 19 |
June 2 |
May 29 |
June 30 |
July 14 |
July 10 |
August 11 |
August 25 |
August 21 |
September 22 |
October 6 |
October 2 |
November 3 |
November 17 |
November 13 |
December 22 |
2020 nhrMAX Panel Run Schedule
Panel |
Test Dates |
Compounds & PO Due |
Report & Invoicing |
nhrMAX
|
February 11 |
February 7 |
March 10 |
March 24 |
March 20 |
April 21 |
May 5 |
May 1 |
June 2 |
June 16 |
June 12 |
July 14 |
July 28 |
July 24 |
August 25 |
September 8 |
September 4 |
October 6 |
October 20 |
October 16 |
November 17 |