Ready to Use Bioassays for Biosimilars & Biobetters

Simple, Rapid, Robust, and Reproducible Assays
 

Accelerate assay development for potency measurement and QC lot release testing with cell-based assays that use a simple, no-wash protocol to provide results in a few hours. Assays are available either as continuous culture cell lines or as bioassay kits. The bioassay kits increase the convenience and reproducibility of the assay by including cryopreserved ready-to-use cells. These assays have enabled multiple global clients to rapidly develop and successfully transfer precise, robust and accurate potency assays for use in QC lot release testing of their biosimilar drug.
 
 
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INN Drug Name Qualified With Molecular Mechanism of Action Assay Measures Qualification Data Bioassay Kits Configuration
Anakinra Kineret® IL-1RA (Inhibits IL-1) IL1R/IL1RAP Dimerization Request Data 93-1032Y3-00105 2-plate
93-1032Y3-00106 10-plate
Darbepoetin Alfa Aranesp® EPOR agonist EpoR/EpoR Dimerization View data 93-0965Y3-00019 2-plate
93-0965Y3-00020 10-plate
Epoetin Alfa Recombinant hEpo EPOR agonist EpoR/EpoR Dimerization View data 93-0965Y3-00017 2-plate
93-0965Y3-00018 10-plate
Somatotropin, Somatropin Recombinant hGH GHR agonist SH2 Recruitment View data 93-0756Y3-00023 2-plate
93-0756Y3-00024 10-plate
Exenatide Byetta® GLP1R agonist cAMP Accumulation Request Data 95-0062Y2-00101 2-plate
95-0062Y2-00102 10-plate
Liraglutide Victoza® GLP1R agonist cAMP Accumulation Request Data 95-0062Y2-00099 2-plate
95-0062Y2-00100 10-plate
Insulin Glargine USP Insulin INSRb agonist SH2 Recruitment View data 93-0466Y3-00011 2-plate
93-0466Y3-00012 10-plate
Insulin Lispro USP Insulin INSRb agonist SH2 Recruitment View data 93-0466Y3-00009 2-plate
93-0466Y3-00010 10-plate
Insulin USP Insulin INSRb agonist SH2 Recruitment View data 93-0466Y3-00007 2-plate
93-0466Y3-00008 10-plate
Parathyroid Hormone (PTH) Recombinant hPTH PTHR agonist β-Arrestin Recruitment Request Data 93-0315Y2-00047 2-plate
93-0315Y2-00048 10-plate
Aflibercept Eylea® VEGF-Trap VEGFR2 (KDR) Dimerization View data 93-0996Y1-00005 2-plate
93-0996Y1-00006 10-plate
Ranibizumab Lucentis® Anti-VEGFA mAb VEGFR2 (KDR) Dimerization View data 93-0996Y1-00003 2-plate
93-0996Y1-00004 10-plate
Bevacizumab Avastin® Anti-VEGFA mAb VEGFR2 (KDR) Dimerization View data 93-0996Y1-00001 2-plate
93-0996Y1-00002 10-plate
Panitumumab ‎Vectibix® Anti-EGFR mAb EGFR/ErbB2 Dimerization Request Data 93-1051Y3-00093 2-plate
93-1051Y3-00094 10-plate
Pertuzumab Perjeta® Anti-HER2-dimerization mAb ErbB2/ErbB3 Dimerization Request Data 93-1042Y3-00095 2-plate
93-1042Y3-00096 10-plate
Teriparatide ‎Forteo® PTHR agonist cAMP Accumulation Request Data 95-0118Y2-00057 2-plate
95-0118Y2-00058 10-plate
Follitropin alfa Gonal-F FSHR agonist cAMP Accumulation Request Data 95-0119Y2-00103 2-plate
95-0119Y2-00104 10-plate
Target Molecular Mechanism of Action Assay Measures Bioassay Kits Configuration
IGF1R agonist drugs SH2 Recruitment 93-0505Y1-00069 2-plate
93-0505Y1-00070 10-plate
NPY2R agonist, antagonist drugs β-Arrestin Recruitment 93-0212Y2-00065 2-plate
93-0212Y2-00066 10-plate
NPY2R agonist, antagonist drugs cAMP Accumulation 95-0077Y2-00055 2-plate
95-0077Y2-00056 10-plate
IL17RA/IL17RC anti-ligand (IL17A, IL17-F) drugs Ligand-Induced Receptor Dimerization (IL17RA/IL17RC) 93-0999Y3-00053 2-plate
93-0999Y3-00054 10-plate
IL2RB/IL2RG/IL2RA modified agonists; anti-IL2 drugs Ligand-Induced Receptor Heterooligomerization (IL2RB/IL2RG/IL2RA) 93-1003Y3-00091 2-plate
93-1003Y3-00092 10-plate
IL6R/IL6ST Anti-IL-6 mAbs IL6RA/IL6ST dimerization 93-1045Y3-00043 2-plate
93-1045Y3-00044 10-plate
IL31RA/OSMRb anti-ligand (IL-31); anti-receptor drugs ligand-induced receptor dimerization (IL31RA/OSMRb) 93-1002Y3-00083 2-plate
93-1002Y3-00084 10-plate
C5AR1 anti-ligand (anti-C5a) β-Arrestin Recruitment 93-0557Y2-00059 2-plate
93-0557Y2-00060 10-plate
CCR2 antagonist drugs β-Arrestin Recruitment 93-0192Y2-00061 2-plate
93-0192Y2-00062 10-plate
CXCR5 antagonist drugs β-Arrestin Recruitment 93-0514Y2-00063 2-plate
93-0514Y2-00064 10-plate
SSTR2 agonist drugs β-Arrestin Recruitment 93-0181Y2-00067 2-plate
93-0181Y2-00068 10-plate
FGFR4-β-Klotho agonist drugs SH2 Recruitment 93-1060Y3-00089 2-plate
93-1060Y3-00090 10-plate
PDGFRA antagonist drugs SH2 Recruitment 93-0823Y3-00071 2-plate
93-0823Y3-00072 10-plate
PDGFRB antagonist drugs SH2 Recruitment 93-0493Y3-00073 2-plate
93-0493Y3-00074 10-plate
TrkB-p75 antagonist drugs SH2 Recruitment 93-0530Y3-00075 2-plate
93-0530Y3-00076 10-plate
TrkC antagonist drugs SH2 Recruitment 93-0464Y3-00077 2-plate
93-0464Y3-00078 10-plate
MC4R antagonist drugs β-Arrestin Recruitment 93-0211Y3-00085 2-plate
93-0211Y3-00086 10-plate
VIPR2 agonist drugs β-Arrestin Recruitment 93-0317Y2-00087 2-plate
93-0317Y2-00088 10-plate
Exendin-4 agonist drugs β-Arrestin Recruitment 93-0300Y2-00029 2-plate
93-0300Y2-00030 10-plate
GLP1R agonist drugs β-Arrestin Recruitment 93-0300Y2-00027 2-plate
93-0300Y2-00028 10-plate
INN Drug Name Molecular Mechanism of Action Assay Measures Cell Line Request Early Access
Adalimumab Anti-TNFa mAb IkB Degradation 93-0538C15 Request Info
Canakinumab Anti-IL-1b mAb IkB Degradation 93-0538C15 Request Info
Canakinumab Anti-IL-1b mAb IL1R/IL1RAP Dimerization 93-1032C3 Request Info
Certolizumab pegol Anti-TNFa mAb IkB Degradation 93-0538C15 Request Info
Cetuximab Anti-EGFR mAb Anti-EGFR mAb 93-1051C3 Request Info
Denosumab Anti-RANKL mAb IkB Degradation 93-0994C3 Request Info
Etanercept Anti-TNFa mAb IkB Degradation 93-0538C15 Request Info
Follicle Stimulating Hormone FSHR agonist cAMP Accumulation 93-0517C2 Request Info
Glucagon GCGR agonist cAMP Accumulation 95-0042C2 Request Info
Glucagon GCGR agonist β-Arrestin Recruitment 93-0241C2 Request Info
Golimumab Anti-TNFa mAb IkB Degradation 93-0538C15 Request Info
Growth-Hormone-Releasing Factor GHRHR agonist cAMP Accumulation 95-0076C2 Request Info
Human Chorionic Gonadotropin (hCG) LHCGR agonist cAMP Accumulation 95-0106C2 Request Info
Human Chorionic Gonadotropin (hCG) LHCGR agonist β-Arrestin Recruitment 93-0957C2 Request Info
Infliximab Anti-TNFa mAb IkB Degradation 93-0538C15 Request Info
Lutropin LHCGR agonist cAMP Accumulation 95-0106C2 Request Info
Lutropin LHCGR agonist β-Arrestin Recruitment 93-0957C2 Request Info
Rituximab anti-CD20 mAb ADCC 97-1012P026 Request Info
Trastuzumab Anti-HER2 mAb ADCC In development Request Info