| Biological Information | |
|---|---|
| Background Information: | Two SR Protein-specific Kinases, SRPK1 and SRPK2, have been shown to phosphorylate specifically the RS motifs of the SR family of splicing factors. Phosphorylation of an SR protein (ASF/SF2) by either SRPk1 or 2 enhanced its interaction with another RS domain-containing protein, and overexpression of either kinase induced specific redistribution of splicing factors in the nucleus. SRPK1 is considered to be a constitutively active kinase predominantly active in testis. Inhibition of SRPK1 may render male germ cell and other tumors insensitive to cisplatin.
GenBank NM_003137 |
| Target Class: | Kinase |
| Accession Number: | NM_003137.3 |
| Target Name: | SRPK1 |
| Target Aliases: | SRPK1SFRSK1 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
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SRPK1, active
N-terminal GST-tagged recombinant, human SRPK1.
Datasheets
14-564x Datasheet
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