PathHunter® U2OS TIM3/TIM3 Dimerization Cell Line

The PathHunter® U2OS TIM3/TIM3 Dimerization Cell Line measures ligand-induced dimerization of the two target proteins. eXpress kits contain all assay materials: cells, reagents, and plates.

Catalog #: 93-1082C3 Size: 2 vials
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Biological Information
Background Information:
The PathHunter® TIM3/TIM3 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand induced dimerization of TIM3/TIM3 receptors. This product uses EFC technology. The cell line included overexpresses TIM3 target protein fused to PK alongside TIM3 target protein fused to EA. Upon ligand-induced dimerization of TIM3/TIM3 , detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:
Checkpoint Receptor
Family:
T cell Receptor (inhibitory)
Accession Number:
NM_032782.4
Target Name:
TIM3/TIM3
Target Aliases:
T-cell immunoglobulin mucin receptor 3, CD366, HAVcr-2, KIM-3, SPTCL, HAVCR2, TIMD-3, TIMD3, Tim-3
Target Species:
Human
Cell Background:
U2OS
Usage
Product Type:
Stable Cell Lines
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage Disclaimer:
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Functional
Assay Measures:
Dimerization
Detection Method:
Chemiluminescence
Additional Information
Brand:
PathHunter®

User Manuals & Protocols

70-303 PathHunter Dimerization Assay REV3 User Manual

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Datasheets

93-1082C3 Datasheet

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