PathHunter® U2OS TIM3/TIM3 Dimerization Cell Line

The PathHunter® U2OS TIM3/TIM3 Dimerization Cell Line measures ligand-induced dimerization of the two target proteins. eXpress kits contain all assay materials: cells, reagents, and plates.

Catalog #: 93-1082C3 Size: 2 vials

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Biological Information
Background Information:	The PathHunter® TIM3/TIM3 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand induced dimerization of TIM3/TIM3 receptors. This product uses EFC technology. The cell line included overexpresses TIM3 target protein fused to PK alongside TIM3 target protein fused to EA. Upon ligand-induced dimerization of TIM3/TIM3 , detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	Checkpoint Receptor
Family:	T cell Receptor (inhibitory)
Accession Number:	NM_032782.4
Target Name:	TIM3/TIM3
Target Aliases:	T-cell immunoglobulin mucin receptor 3, CD366, HAVcr-2, KIM-3, SPTCL, HAVCR2, TIMD-3, TIMD3, Tim-3
Target Species:	Human
Cell Background:	U2OS

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	Dimerization
Detection Method:	Chemiluminescence

Additional Information
Brand:	PathHunter®