PathHunter® U2OS IFNGR1/IFNGR2 Dimerization Cell Line

The PathHunter® U2OS IFNGR1/IFNGR2 Dimerization Cell Line measures ligand-induced dimerization of IFNGR1/IFNGR2 . This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-1098C3 Size: 2 vials

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Biological Information
Background Information:	The PathHunter® IFNGR1/IFNGR2 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IFN-g) induced dimerization of IFNGR1/IFNGR2 receptors. This product uses EFC technology. The cell line included overexpresses IFNGR1 target protein fused to PK alongside IFNGR2 target protein fused to EA. Upon ligand-induced dimerization of IFNGR1/IFNGR2 , detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	Cytokine Receptor
Family:	Interferon Receptor Family
Accession Number:	NM_000416.2
Target Name:	IFNGR1/IFNGR2
Target Aliases:	interferon receptor, interferon gamma receptor 1, interferon gamma receptor 2, CD119, IFNGR, IMD27A, IMD27B, AF-1, IFGR2, IFNGT1, IMD28
Target Species:	Human
Cell Background:	U2OS

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	Dimerization
Detection Method:	Chemiluminescence

Clinical Relevance
Therapeutic Area:	Inflammation/Allergy

Additional Information
Brand:	PathHunter®