Biological Information

Background Information:

The PathHunter® ACVR1B/BMPR2  Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. activin A) induced dimerization of ACVR1B/BMPR2  receptors. This product uses EFC technology. The cell line included overexpresses ACVR1B target protein fused to PK alongside BMPR2  target protein fused to EA. Upon ligand-induced dimerization of ACVR1B/BMPR2  , detectable EFC signal is produced.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Kinase

Family:

RSTK

Sub Family:

Protein Ser/Thr

Protein Name:

ALK4

Protein Aliases:

Activin receptor type IB|ACTR-IB|Activin receptor-like kinase 4|ALK-4|Serine/threonine-protein kinase receptor R2|SKR2

Accession Number:

NM_004302.4

UniProt Number:

P36896

Gene Name:

ACVR1B

Gene ID:

91

Gene Aliases:

ALK4|SKR2|ActRIB|ACVRLK4

Target Species:

Human

Cell Background:

U2OS

Usage

Product Type:

Stable Cell Lines

Application:

Drug Discovery & Development

Storage Conditions:

Store in vapor phase of liquid nitrogen.

Usage disclaimer:

These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information

Assay Type:

Cell Based

Assay Measures:

Dimerization

Detection Method:

Chemiluminescence

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology

Additional Information

Brand:

PathHunter®