PathHunter® AVPR1A Total GPCR Internalization U2OS Cell Line

Background Information:

The PathHunter® AVPR1A Total GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line enables assessment of ligand (e.g. vasopressin) based internalization of AVPR1A via detection of localization to the early endosome. This product uses EFC technology. The included cell line overexpresses PK-tagged AVPR1A and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the AVPR1A receptor to the early endosome leads to production of EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Vasopressin and Oxytocin

Sub Family:

Class A

Coupling:

Gq

Protein Name:

V1A

Protein Aliases:

AVPR V1a|Antidiuretic hormone receptor 1a|Vascular/hepatic-type arginine vasopressin receptor

Accession Number:

NM_000706.3

UniProt Number:

P37288

Gene Name:

AVPR1A

Gene ID:

552

Gene Aliases:

AVPR1

Target Species:

Human

Cell Background:

U2OS