The PathHunter® AVPR1A Total GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line enables assessment of ligand (e.g. vasopressin) based internalization of AVPR1A via detection of localization to the early endosome. This product uses EFC technology. The included cell line overexpresses PK-tagged AVPR1A and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the AVPR1A receptor to the early endosome leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.
Vasopressin & Oxytocin Receptors
arginine vasopressin receptor 1AV1aRAVPR1AVPR V1a
Stable Cell Lines
Drug Discovery & Development
Short term (24 h): Store in vapor phase of liquid nitrogen.
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
PathHunter® AVPR1A Total GPCR Internalization U2OS Cell Line
User Manuals & Protocols