The PathHunter® β-Arrestin2 Retroparticles are MMLV particles designed to transduce cells of interest with β-Arrestin2 fused to EA. In conjunction with a plasmid expressing a PK-tagged GPCR of interest, this allows for these cells to be used for β-Arrestin2 recruitment assays. This product uses EFC technology (https://www.discoverx.com/technologies-platforms/enzyme-fragment-complementation-technology). Ligand induced recruitment of β-Arrestin2 to the activated GPCR leads to complementation and produces EFC signal. These retroparticles ship as 4 vials of cryopreserved retroparticles.
Drug Discovery & Development
Short term (24 h): Store in vapor phase of liquid nitrogen.
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PathHunter® β-Arrestin2 Retroparticles
The PathHunter® β-Arrestin2 Retroparticles are retroparticles for transducing cells with β-Arrestin2-EA to allow for arrestin recruitment assays. This product contains 4 vials of cryopreserved retroparticles.