InCELL Hunter™ HEK 293 FGR Kinase Binding Cell Line

Background Information:

The InCELL Hunter™ HEK 293 FGR Kinase Binding Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with kinases. This cell line enables assessment of compound-engagement-based stabilization of FGR via detection of FGR levels. This product uses EFC technology. The cell line included overexpresses FGR target protein fused to PL. In the absence of compound that binds and stabilizes the target, this protein is denatured by the heat treatment and no EFC signal is produced. When compound engages and heat-stabilizes the target, EA contained in the detection reagent produces EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Kinase

Family:

TK

Sub Family:

Protein Tyrosine

Protein Name:

FGR

Protein Aliases:

Gardner-Rasheed feline sarcoma viral|v-fgr oncogene homolog|Proto-oncogene c-Fgr|p55-Fgr|p58-Fgr|p58c-Fgr

Accession Number:

NM_000163

UniProt Number:

P09769

Gene Name:

FGR

Gene ID:

2268

Gene Aliases:

c-fgr|p55c-fgr

Target Species:

Human

Cell Background:

HEK293