InCELL Hunter™ HEK 293 BRDT(1,2) Bromodomain Cell Line

Background Information:

The InCELL Hunter™ HEK 293 BRDT(1,2) Bromodomain Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with regulators of epigenetics pathways. This cell line enables assessment of compound-engagement-based stabilization of BRDT(1,2) via detection of BRDT(1,2) levels. This product uses EFC technology. The cell line included overexpresses BRDT(1,2) target protein fused to PL. In the absence of compound that binds and stabilizes the target, this protein is degraded and no EFC signal is produced. When compound engages and stabilizes the target, EA contained in the detection reagent produces EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Epigenetic

Family:

Bromodomain-Containing

Sub Family:

Reader

Protein Name:

BRDT

Protein Aliases:

cancer/testis antigen 9

Accession Number:

NM_001726

UniProt Number:

Q58F21

Gene Name:

BRDT

Gene ID:

676

Gene Aliases:

BRD6|CT9

Target Species:

Human

Cell Background:

HEK293