EphA8, active

N-terminal 6His-tagged recombinant, human EphA8 amino acids 615-911.

Catalog #: 14-673


Biological Information
Background Information:
Eph (erythropoietin-producing hepatocellular) family tyrosine kinase receptors consist of two groups: EphA group members respond to ephrin-A, which is anchored to the cell membrane by glycosylphosphatidylinositol, whereas EphB group members respond to ephrin-B, containing a transmembrane domain. Among them, only EphA4 can cross-respond to both ephrin-A and -B. The expression of EphA8 receptor significantly promoted cell attachment to fibronectin without altering cellular integrin levels. Moreover, p110 phosphatidylinositol (PI) 3-kinase plays as a key bridging molecule between EphA8 and integrins. Inhibition. of EphA8 may disrupt establishment, maintenance, and remodeling of patterns of cellular organization and may also be used in the treatment of various cancers. GenBank NM_020526
Target Class:
Receptor Typosine Kinase (RTK): Growth Factor Receptor
Accession Number:
NM_001006943.1; NM_020526.3
Target Name:
Target Aliases:
EPHA8, HEK3, KIAA1459, EphA8, EEK, Hek3
Target Species:
Product Type:
Drug Discovery & Development
Storage Conditions:
6 months at -70°C
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14-673x Datasheet

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