Biological Information

Background Information:

Eph (erythropoietin-producing hepatocellular) family tyrosine kinase receptors consist of two groups: EphA group members respond to ephrin-A, which is anchored to the cell membrane by glycosylphosphatidylinositol, whereas EphB group members respond to ephrin-B, containing a transmembrane domain. Among them, only EphA4 can cross-respond to both ephrin-A and -B. The expression of EphA8 receptor significantly promoted cell attachment to fibronectin without altering cellular integrin levels. Moreover, p110 phosphatidylinositol (PI) 3-kinase plays as a key bridging molecule between EphA8 and integrins. Inhibition. of EphA8 may disrupt establishment, maintenance, and remodeling of patterns of cellular organization and may also be used in the treatment of various cancers. GenBank NM_020526

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

EphA8

Protein Aliases:

EPH- and ELK-related kinase|EPH-like kinase 3|EK3|hEK3|Tyrosine-protein kinase receptor EEK

Accession Number:

NM_001006943.1; NM_020526.3

UniProt Number:

P29322

Gene Name:

EPHA8

Gene ID:

2046

Gene Aliases:

Hek3

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

6 months at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology