ALK2, active

Background Information:

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. GenBank NM_001105

Target Class:

Kinase

Family:

RSTK

Sub Family:

Protein Ser/Thr

Protein Name:

ALK2

Protein Aliases:

Activin receptor type I|ACTR-I|Activin receptor-like kinase 2|ALK-2|Serine/threonine-protein kinase receptor R1|SKR1|TGF-B superfamily receptor type I|TSR-I

Accession Number:

NM_001105

UniProt Number:

Q04771

Gene Name:

ACVR1

Gene ID:

90

Gene Aliases:

SKR1|ALK2|ACVR1A

Target Species:

Human