| Biological Information | |
|---|---|
| Background Information: | ACK1, also known as TNK2 (Tyrosine Kinase Non Receptor 2), is a non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway.
GenBank NM_005781 |
| Target Class: | Kinase |
| Accession Number: | NM_001010938.1; NM_005781.4 |
| Target Name: | ACK1 |
| Target Aliases: | TNK2, FLJ44758, ACK1, p21cdc42Hs, ACK, ACK-1, FLJ45547 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
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ACK1, active
N-terminal GST-tagged recombinant, human ACK1, amino acids 1-389.
Datasheets
14-756x Datasheet
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