ACK1, active

Background Information:

ACK1, also known as TNK2 (Tyrosine Kinase Non Receptor 2), is a non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. GenBank NM_005781

Target Class:

Kinase

Family:

TK

Sub Family:

Protein Tyrosine

Protein Name:

ACK1

Protein Aliases:

activated Cdc42-associated kinase 1

Accession Number:

NM_001010938.1; NM_005781.4

UniProt Number:

Q07912

Gene Name:

TNK2

Gene ID:

10188

Gene Aliases:

p21cdc42Hs|ACK|ACK1

Target Species:

Human