1321N1 P2RY1 Gq Cell Line

The 1321N1 P2RY1 Gq Cell Line measures P2RY1 (GPCR) activity via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.

Catalog #: 95-1018C6 Size: 2 vials

Biological Information
Background Information:	The 1321N1 P2RY1 Gq cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. ATP) based activation of P2RY1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses P2RY1 , a naturally Gq coupled GPCR. Upon activation of P2RY1 , the resulting calcium activity can be fluorescently assayed using the Calcium NoWash PLUS Detection Kit. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	GPCR
Family:	P2Y Receptors
Sub Family:	Class A
Coupling:	Gq
Accession Number:	NM_002563.2
Target Name:	P2RY1
Target Aliases:	Purinergic receptor P2YG-protein coupled1
Target Species:	Human
Cell Background:	1321N1

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Short term (24 h): Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	Calcium Flux
Detection Method:	Chemiluminescence

Additional Information
Brand:	DiscoverX