Biological Information | |
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Background Information: | IRAK (IL-1 Receptor Associated Kinase 1) is a Ser/Thr kinase which associates with the IL-1 Receptor subunits after IL-1 binding, by virtue of the adapter protein MyD88. Three IRAK molecules, IRAK1, IRAK2, and IRAK-M, can relay the NF-&kB-activating signal via TNFR-associated factor 6 (TRAF6) and TGF-b-activated kinase 1 to the IKK complex, which ultimately mediates NF-&kB activation. Inhibition of IRAK1 may reduce inflammation as well as apoptosis.
GenBank NM_001569 |
Target Class: | Kinase |
Accession Number: | NM_001025242.1; NM_001025243.1; NM_001569.3 |
Target Name: | IRAK1 |
Target Aliases: | IRAK1, IRAK, IRAK-1, pelle |
Target Species: | Human |
Usage | |
Product Type: | Enzymes |
Application: | Drug Discovery & Development |
Storage Conditions: | 6 months at -70°C |
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Datasheets
14-684x Datasheet
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