Biological Information

Background Information:

UbcH5c is a ubiquitin-conjugating enzyme (E2) that plays a central role in the ubiquitin–proteasome system (UPS), the major pathway for selective protein degradation in eukaryotic cells. It functions downstream of E1 ubiquitin-activating enzymes and upstream of E3 ubiquitin ligases to catalyze the covalent attachment of ubiquitin to substrate proteins. UbcH5c belongs to the UBE2D (UbcH5) subfamily, which includes UbcH5a, UbcH5b , and UbcH5d. These enzymes are highly conserved and functionally promiscuous, partnering with a wide range of RING-type E3 ligases. UbcH5c cooperates with E3 ligases like MDM2 and BRCA1, influencing tumor suppressor p53 stability and DNA repair. Modulating its activity can indirectly affect oncogenic or tumor-suppressive signaling.

Target Class:

Ubiquitination-related

Family:

ubiquitin-conjugating enzyme

Sub Family:

Transferase

Protein Name:

UbcH5c

Protein Aliases:

UBC5C

Accession Number:

NM_181888.2

UniProt Number:

P61077

Gene Name:

UBE2D3

Gene ID:

7323

Gene Aliases:

UBC4/5; UBCH5C; E2(17)KB3

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Assay Measures:

ECL

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Oncology