Biological Information

Background Information:

Active RIPK5. N-Terminal 6His-tagged, recombinant, full length, human RIPK5. RIPK5 acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation and is involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. Rare variants of the kinase are associated with human congenital anomalies of the kidney and urinary tract. Recent studies indicate that RIPK5 is a therapeutic target for a number of cancers including breast, colorectal and non-small cell lung cancer.

Target Class:

Kinase

Family:

TKL

Sub Family:

Serine/threonine/tyrosine kinase

Protein Name:

RIPK5

Protein Aliases:

DSTYK; dusty PK; sgK496

Accession Number:

BC117411.1

UniProt Number:

Q6XUX3

Gene Name:

DSTYK

Gene ID:

25778

Gene Aliases:

RIP5; RIPK5; SPG23; CAKUT1; RHDNS1; DustyPK; HDCMD38P

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Assay Measures:

Radiometric, ADP Accumulation

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Oncology