PTP-1B

Background Information:

PTP-1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. GenBank NM_002827

Target Class:

Phosphatase

Family:

Non-Receptor

Sub Family:

Protein Tyrosine

Protein Name:

PTP1B

Accession Number:

NM_002827.2

UniProt Number:

P18031

Gene Name:

PTPN1

Gene ID:

5770

Target Species:

Human