Biological Information
Background Information:
N-terminal 6His-tagged, recombinant, human PRP4, amino acids 663-end. PRP4 is a member of the serine/threonine protein kinase family. It is a transcription factor involved in pre-mRNA splicing. Shares homology with cyclin-dependent kinases and mitogen-activated protein kinases and is thought to be essential for regulating cell growth and survival of some cancers. Reported to be involved in reversing anti-cancer drug-induced cell death in human cancer cell lines through actin cytoskeleton rearrangement and epithelial-mesenchymal transition (EMT).
Target Class:
Kinase
Family:
CMGC
Sub Family:
Serine/threonine kinase
Protein Name:
PRP4
Protein Aliases:
PRP4 kinase|PRP4 pre-mRNA-processing factor 4 homolog
Accession Number:
NM_176800.1
UniProt Number:
Q13523
Gene Name:
PRPF4B
Gene ID:
8899
Gene Aliases:
Prp4|PR4H|KIAA0536|PRP4H|PRP4K
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
1 year at -70°C
Usage disclaimer:
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Clinical Relevance
Therapeutic Area:
Oncology/Immuno-Oncology