Biological Information

Background Information:

N-terminal 6His-tagged, recombinant, human PRP4, amino acids 663-end. PRP4 is a member of the serine/threonine protein kinase family. It is a transcription factor involved in pre-mRNA splicing. Shares homology with cyclin-dependent kinases and mitogen-activated protein kinases and is thought to be essential for regulating cell growth and survival of some cancers. Reported to be involved in reversing anti-cancer drug-induced cell death in human cancer cell lines through actin cytoskeleton rearrangement and epithelial-mesenchymal transition (EMT).

Target Class:

Kinase

Family:

CMGC

Sub Family:

Serine/threonine kinase

Protein Name:

PRP4

Protein Aliases:

PRP4 kinase|PRP4 pre-mRNA-processing factor 4 homolog

Accession Number:

NM_176800.1

UniProt Number:

Q13523

Gene Name:

PRPF4B

Gene ID:

8899

Gene Aliases:

Prp4|PR4H|KIAA0536|PRP4H|PRP4K

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology