PP1alpha

Background Information:

PP1α protein is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. GenBank NM_002708. The PP1alpha protein sequence is identical to the human PP1 alpha described in GenBank NM_002708. The DNA sequence, however, is more closely related to the rabbit cDNA described in GenBank X14832.

Target Class:

Phosphatase

Sub Family:

Protein Ser/Thr

Protein Name:

PP1alpha

Accession Number:

NM_002708.3

UniProt Number:

P62136

Gene Name:

PPP1CA

Gene ID:

5499

Gene Aliases:

PP1A|PP-1A|PP1alpha

Target Species:

Human