PLK2/SNK, active

Background Information:

N-terminal GST-tagged, recombinant, full length human PLK2/SNK. PLK2/SNK is a serine/threonine protein kinase that plays key roles in the cell cycle, differentiation, ontogenesis and the stress response. PLK2 is significantly down-regulated in a wide range of acute myeloid leukemias and B-cell lymphomas due to aberrant cytosine methylation in the CpG island located at the 5' of the PLK2 gene. PLK2 down-regulation by the microRNA miR-126 also appears to contribute to leukemogenesis, tumorigenesis, neurodegenerative diseases, inflammation and injury.

Target Class:

Kinase

Family:

CDC5/Polo

Sub Family:

Serine/threonine kinase

Protein Name:

PLK2

Protein Aliases:

Polo-like kinase 2

Accession Number:

Genbank NM_006622.4

UniProt Number:

Q9NYY3

Gene Name:

PLK2

Gene ID:

10769

Gene Aliases:

SNK; hSNK; hPlk2

Target Species:

Human