Biological Information

Background Information:

N-Terminal GST-tagged, recombinant, full length, human PDK1 (PDHK1). PDK1 (PDHK1) inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Elevated expression of PDK1 (PDHK1) has been detected in various aggressive cancer types, such as lung cancer, gastric cancer, and myeloma and it is frequently associated with chemotherapy related drug resistance, invasion and metastasis.

Target Class:

Kinase

Family:

PDK/BCKDK

Sub Family:

Serine/threonine kinase

Protein Name:

PDK1

Protein Aliases:

PDK1; PDHK1; PDH kinase 1

Accession Number:

NM_002610.3

UniProt Number:

Q15118

Gene Name:

PDK1

Gene ID:

5163

Gene Aliases:

PDHK1

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology