PDGFRalpha (550-end, V561D), active

Background Information:

PDGFRα (Platelet-Derived Growth Factor Receptor Alpha) is a transmembrane receptor protein that belongs to the family of receptor tyrosine kinases. It is involved in a variety of cellular processes, including cell growth, differentiation, migration, and survival. PDGFRα is expressed in a variety of tissues and cell types, including fibroblasts, smooth muscle cells, and certain types of cancer cells. Aberrant activation of PDGFRα has been implicated in several diseases, including cancer, fibrotic disorders, and vascular diseases. PDGFRα mutations, amplifications, and overexpression have been found in various types of cancer, making it a potential target for cancer therapy. Additionally, drugs that target PDGFRα have been approved for the treatment of certain types of cancer, such as gastrointestinal stromal tumors (GIST) and chronic myelomonocytic leukemia (CMML).

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

PDGFRalpha

Protein Aliases:

PDGFR-alpha|Alpha platelet-derived growth factor receptor|Alpha-type platelet-derived growth factor receptor|CD140 antigen-like family member A|CD140a antigen|Platelet-derived growth factor alpha receptor|Platelet-derived growth factor receptor 2|PDGFR-2|CD antigen CD140a

Accession Number:

NM_006206.3

UniProt Number:

P16234

Gene Name:

PDGFRA

Gene ID:

5156

Gene Aliases:

CD140a|PDGFR2|GAS9|RHEPDGFRA

Target Species:

Human