PathHunter® CHO-K1 FXR Protein Interaction Cell Line

Background Information:

The PathHunter® FXR Protein Interaction cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting NHR activation and recruitment of cofactors. This cell line enables assessment of ligand (e.g. cholic acids) based NHR activation via detection of SRCP (steroid receptor co-activator peptide) recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged FXR NHR and EA-tagged steroid receptor co-activator peptide (SRCP). Upon activation of FXR, induced interaction with SRCP leads to production of EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

NHR

Family:

Liver X Receptor-Like

Sub Family:

Non-Steroid

Protein Name:

FXR

Protein Aliases:

farnesoid X receptor

Accession Number:

NM_005123.3

UniProt Number:

Q96RI1

Gene Name:

NR1H4

Gene ID:

9971

Gene Aliases:

FXR|RIP14|HRR1|HRR-1

Target Species:

Human

Cell Background:

CHO-K1