Biological Information

Background Information:

The PathHunter® cGPR91 (SUCNR1) Cell Pool is a stable, engineered cell pool for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell pool enables assessment of ligand (e.g. succinate) based activation of cGPR91 GPCR activity via detection of β-arrestin recruitment. The included cell pool overexpresses ProLink-tagged cGPR91 and EA-tagged β-Arrestin-2. Activation of cGPR91 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable cell pool is provided as two vials of cryopreserved cells. Please note that this product expresses the Dog version of this protein.

Target Class:

GPCR

Family:

Succinate

Sub Family:

Class A

Protein Name:

SUCNR1 (GPR91)

Accession Number:

XM_542840

UniProt Number:

A0A8I3Q2D1

Gene Name:

SUCNR1

Gene ID:

485719

Target Species:

Dog

Cell Background:

CHO-K1

Usage

Product Type:

Cell Pool

Application:

Drug Discovery & Development

Storage Conditions:

Store in vapor phase of liquid nitrogen.

Usage disclaimer:

These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information

Assay Type:

Cell Based

Assay Measures:

β-Arrestin Recruitment

Detection Method:

Chemiluminescence

Clinical Relevance

Therapeutic Area:

CNS/Addiction/Pain

Additional Information

Brand:

PathHunter®