PAK5, active

Background Information:

PAK5 is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. GenBank NM_020341

Target Class:

Kinase

Family:

STE

Sub Family:

Protein Ser/Thr

Protein Name:

PAK5

Protein Aliases:

p21-activated kinase 5|PAK-5|p21-activated kinase 7|PAK-7

Accession Number:

NM_020341.2; NM_177990.1

UniProt Number:

Q9P286

Gene Name:

PAK5

Gene ID:

57144

Gene Aliases:

KIAA1264

Target Species:

Human