MAP Kinase 1/Erk2, unactive

Background Information:

MAP Kinase 2/Erk2 Protein is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. Involved in both the initiation and regulation of meiosis, mitosis, and post-mitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4). GenBank NM_002745. The cDNA sequence corresponds to a humanized version of the mouse MAP Kinase 2 coding sequence describ4ed in GenBank D10939. At the protein level the sequence is identical to GenBank NM_002745.

Target Class:

Kinase

Family:

CMGC

Sub Family:

Protein Ser/Thr

Protein Name:

ERK2

Protein Aliases:

MAPK 1|Extracellular signal-regulated kinase 2|ERK-2|MAP kinase isoform p42|p42-MAPK|Mitogen-activated protein kinase 2|MAP kinase 2|MAPK 2

Accession Number:

NM_002745.4; NM_138957.2

UniProt Number:

P28482

Gene Name:

MAPK1

Gene ID:

5594

Gene Aliases:

ERK|ERK2|p41mapk|MAPK2|PRKM1|PRKM2

Target Species:

Human