Biological Information
Background Information:
LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. GenBank NM_004690.2 / GenBank BC038112.1
Target Class:
Kinase
Family:
AGC
Sub Family:
Protein Ser/Thr
Protein Name:
LATS1
Protein Aliases:
Large tumor suppressor homolog 1|WARTS protein kinase|h-warts
Accession Number:
NM_004690.2; BC038112.1
UniProt Number:
O95835
Gene Name:
LATS1
Gene ID:
9113
Gene Aliases:
WARTS
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
1 year at -70°C
Usage disclaimer:
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Assay Information
Assay Type:
Enzymatic