LATS1, active

Background Information:

LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. GenBank NM_004690.2 / GenBank BC038112.1

Target Class:

Kinase

Family:

AGC

Sub Family:

Protein Ser/Thr

Protein Name:

LATS1

Protein Aliases:

Large tumor suppressor homolog 1|WARTS protein kinase|h-warts

Accession Number:

NM_004690.2; BC038112.1

UniProt Number:

O95835

Gene Name:

LATS1

Gene ID:

9113

Gene Aliases:

WARTS

Target Species:

Human