Kit

Background Information:

Kit is a receptor tyrosine kinase that binds the cytokine ligand KITLG/SCF, leading to receptor dimerisation, autophosphorylation, and activation of downstream signalling pathways including PI3K-AKT, RAS-RAF-MAPK, and JAK-STAT. It plays key roles in hematopoiesis, mast cell development, melanogenesis, gametogenesis, and stem?cell maintenance. Activating mutations or over-expression of Kit are implicated in several malignancies such as gastrointestinal stromal tumour (GIST), melanoma, mastocytosis, and acute myeloid leukaemia.

Target Class:

Ubiquitination-related

Family:

CSF-1/PDGF receptor

Sub Family:

Tyrosine kinase

Protein Name:

Kit

Protein Aliases:

SCFR; c-Kit; p145 c-kit; PBT; CD117

Accession Number:

X06182.1

UniProt Number:

P10721

Gene Name:

KIT

Gene ID:

3815

Gene Aliases:

PBT; SCFR; C-Kit; CD117; MASTC

Target Species:

Human