GLP1R, active

Background Information:

The glucagon‑like peptide‑1 receptor (GLP1R) is a class B GPCR essential for metabolic regulation and glucose homeostasis. Activated by the incretin hormone GLP‑1, released from intestinal L‑cells after nutrient intake, GLP1R primarily couples to Gαs, elevating intracellular cAMP through adenylyl cyclase activation. This signaling enhances glucose‑dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and promotes satiety, making GLP1R a key regulator of postprandial glucose control and overall metabolic balance. The receptor is expressed in pancreatic islets, the gastrointestinal tract, and CNS regions governing appetite and energy regulation, integrating hormonal and neural pathways that influence glucose metabolism, body weight, and energy intake.
Because of its central metabolic functions, GLP1R is a major therapeutic target in endocrinology. GLP1R agonists form the basis of several effective treatments for Type 2 diabetes and obesity, improving glycemic control while supporting clinically meaningful weight loss. With strong clinical validation and expanding therapeutic potential, GLP1R continues to be a primary focus of metabolic drug discovery.
Our recombinant full‑length GLP1R is produced in a eukaryotic expression system to maintain native folding and appropriate post‑translational modifications, including glycosylation. The purified, wild‑type receptor remains structurally and functionally intact. This high‑quality preparation is ideal for biochemical, structural, and pharmacological studies, enabling ligand screening, antibody discovery, and mechanistic research on this clinically significant GPCR.

Target Class:

GPCR

Sub Family:

Class B

Protein Name:

GLP1R

Protein Aliases:

GLP-1 receptor; GLP-1-R; GLP-1R

UniProt Number:

P43220

Gene Name:

GLP1R

Gene ID:

2740

Gene Aliases:

GLP-1; GLP-1R; GLP-1-R

Target Species:

Human