DDX3X, active

Background Information:

DDX3X is a multifunctional ATP-dependent RNA helicase that is able to regulate almost all stages of RNA metabolism, including transcription, pre-mRNA splicing, RNA export and translation. Dysfunction of the helicase has been shown to be important in various diseases, including viral infection, inflammation, intellectual disability and cancer. It has been demonstrated that DDX3X is overexpressed in many types of cancer including glioma, medulloblastoma, meningioma, head and neck squamous cell carcinoma, lung cancer, breast cancer, hepatocellular carcinoma, gallbladder carcinoma, pancreatic ductal adenocarcinoma, colorectal cancer, prostate cancer and sarcoma.

Target Class:

DEAD box helicase

Family:

DDX3/DED1

Sub Family:

RNA helicase

Protein Name:

DDX3X

Protein Aliases:

ATP-dependent RNA helicase DDX3X

Accession Number:

GenBank NM_001356.5

UniProt Number:

O00571

Gene Name:

DDX3X

Gene ID:

1654

Gene Aliases:

DBX; DDX3; HLP2; DDX14; CAP-Rf; MRX102; MRXSSB

Target Species:

Human