Biological Information
Background Information:
DDX3X is a multifunctional ATP-dependent RNA helicase that is able to regulate almost all stages of RNA metabolism, including transcription, pre-mRNA splicing, RNA export and translation. Dysfunction of the helicase has been shown to be important in various diseases, including viral infection, inflammation, intellectual disability and cancer. It has been demonstrated that DDX3X is overexpressed in many types of cancer including glioma, medulloblastoma, meningioma, head and neck squamous cell carcinoma, lung cancer, breast cancer, hepatocellular carcinoma, gallbladder carcinoma, pancreatic ductal adenocarcinoma, colorectal cancer, prostate cancer and sarcoma.
Target Class:
DEAD box helicase
Family:
DDX3/DED1
Sub Family:
RNA helicase
Protein Name:
DDX3X
Protein Aliases:
ATP-dependent RNA helicase DDX3X
Accession Number:
GenBank NM_001356.5
UniProt Number:
O00571
Gene Name:
DDX3X
Gene ID:
1654
Gene Aliases:
DBX; DDX3; HLP2; DDX14; CAP-Rf; MRX102; MRXSSB
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
1 year at -70°C
Usage disclaimer:
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Assay Information
Assay Type:
Enzymatic
Clinical Relevance
Therapeutic Area:
Oncology/Immuno-Oncology/Inflammation