ChemiSCREEN™ CXCR5 Chemokine Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ CXCR5 Chemokine Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CXCL13/BCA-1/BLC) based activation of CXCR5 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CXCR5 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CXCR5 , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Chemokine

Sub Family:

Class A

Protein Name:

CXCR5

Protein Aliases:

CXCR-5|Burkitt lymphoma receptor 1|Monocyte-derived receptor 15|MDR-15|CD antigen CD185

Accession Number:

NM_001716

UniProt Number:

P32302

Gene Name:

CXCR5

Gene ID:

643

Gene Aliases:

MDR15|CD185

Target Species:

Human

Cell Background:

Chem-10