ChemiSCREEN™ CCR1 Chemokine Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ CCR1 Chemokine Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CCL3) based activation of CCR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CCR1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CCR1 , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Chemokine

Sub Family:

Class A

Protein Name:

CCR1

Protein Aliases:

CC-CKR-1|CCR-1|CCR1|HM145|LD78 receptor|Macrophage inflammatory protein 1-alpha receptor|MIP-1alpha-R|RANTES-R|CD antigen CD191

Accession Number:

L09230

UniProt Number:

P32246

Gene Name:

CCR1

Gene ID:

1230

Gene Aliases:

CKR-1|MIP1aR|CD191

Target Species:

Human

Cell Background:

Chem-1