cAMP Hunter™ eXpress Cyno GLP1R Gs Assay (CHO-K1)

Background Information:

The cAMP Hunter™ cyno GLP1R eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. exendin-4) based activation of cyno GLP1R GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type cyno GLP1R, a naturally Gs coupled GPCR. Upon activation of GLP1R, the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied.
eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. Please note that this product expresses the cyno version of this receptor.

Target Class:

GPCR

Family:

Glucagon

Sub Family:

Class B

Coupling:

Gs

Protein Name:

GLP-1

Protein Aliases:

GLP-1 receptor|GLP-1-R|GLP-1R

Accession Number:

XP_045246742.1

UniProt Number:

A0A2K5WDY5

Gene Name:

GLP1R

Gene ID:

102119087

Target Species:

Cynomolgus Monkey

Cell Background:

CHO-K1