Biological Information

Background Information:

The mammalian Abelson (Abl) family of non-receptor tyrosine kinases is comprised of c-Abl (ABL1) and Arg (Abl-related gene, ABL2), which are encoded by the Abl1 and Abl2 genes, respectively. Deregulation of the c-Abl and Arg tyrosine kinases can occur as a result of chromosomal translocation events that produce chimeric proteins associated with the development of human leukemias as well as gastric cancer invasion and progression. GenBank NM_005158

Target Class:

Kinase

Family:

TK

Sub Family:

Protein Tyrosine

Protein Name:

Arg

Protein Aliases:

Abelson-related gene

Accession Number:

NM_005158.2; NM_007314.1

UniProt Number:

P42684

Gene Name:

ABL2

Gene ID:

27

Gene Aliases:

ARG

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

6 months at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology