Ready-to-Assay P2Y2 Purinergic Receptor Frozen Cells

Background Information:

The Ready-to-Assay P2Y2 Purinergic Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. ATP, UTP) based activation of P2RY2 GPCR activity via detection of increasing levels of intracellular calcium. The included cells overexpress P2RY2 , a naturally Gq coupled GPCR. Upon activation of P2RY2 , the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format.

Target Class:

GPCR

Family:

P2Y

Sub Family:

Class A

Protein Name:

P2Y2

Protein Aliases:

ATP receptor|P2U purinoceptor 1|P2U1|P2U receptor 1|Purinergic receptor

Accession Number:

NM_002564.2

UniProt Number:

P41231

Gene Name:

P2RY2

Gene ID:

5029

Gene Aliases:

P2U

Target Species:

Human

Cell Background:

1321N1