PAR-1Balpha, active

Background Information:

PAR-1Bα Protein has a role in epithelial morphogenesis. Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1. These isoforms were characterized by the presence of a 162-bp alternative exon that gave rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be coexpressed in a number of selected cell lines and tissue samples. The human EMK1 was shown to be encoded by a single mRNA ubiquitously expressed. GenBank AF387638

Target Class:

Kinase

Family:

CAMK

Sub Family:

Protein Ser/Thr

Protein Name:

MARK2

Protein Aliases:

ELKL motif kinase 1|serine/threonine kinase|protein-serine/threonine kinase|Ser/Thr protein kinase PAR-1B

Accession Number:

NM_001039468.1; NM_001039469.1; NM_004954.3; NM_017490.2

UniProt Number:

Q7KZI7

Gene Name:

MARK2

Gene ID:

2011

Gene Aliases:

PAR-1|Par1b|PAR-1B

Target Species:

Human