MKP5, active

Background Information:

MKP5, also known as DUSP10 (Dual Specificity Phosphatase 10), is a dual specificity protein phosphatase that inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotryosine residues. Dual specificity protein phosphatases negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. GenBank NM_007207

Target Class:

Phosphatase

Family:

Dual Specificity

Sub Family:

Protein Tyrosine

Protein Name:

MKP5

Accession Number:

NM_007207

UniProt Number:

Q9Y6W6

Gene Name:

DUSP10

Gene ID:

11221

Gene Aliases:

MKP-5|MKP5

Target Species:

Human