ChemiSCREEN™ kappa Opioid Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ κ Opioid Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. DADLE, DPDPE) based activation of OPRK1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses OPRK1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of OPRK1 , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Opioid

Sub Family:

Class A

Protein Name:

kappa (KOP)

Protein Aliases:

KOR-1

Accession Number:

AF498922

UniProt Number:

P41145

Gene Name:

OPRK1

Gene ID:

4986

Gene Aliases:

KOR|OPRK

Target Species:

Human

Cell Background:

Chem-1