ChemiSCREEN™ MCH1 Melanin-concentrating Hormone Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ MCH1 Melanin-concentrating Hormone Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. MCH) based activation of MCHR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses MCHR1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of MCHR1 , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Melanin-Concentrating Hormone

Sub Family:

Class A

Protein Name:

MCH1

Protein Aliases:

MCH-R1|MCHR-1|G-protein coupled receptor 24|MCH-1R|MCH1R|MCHR|SLC-1|Somatostatin receptor-like protein

Accession Number:

AY562945

UniProt Number:

Q99705

Gene Name:

MCHR1

Gene ID:

2847

Gene Aliases:

SLC1|MCH1R

Target Species:

Human

Cell Background:

Chem-1