CaM Kinase IV, active

Background Information:

Ca2+/Calmodulin-Dependent Kinase family includes CaM Kinases I through IV. All CaM kinases are able to phosphorylate nuclear transcription factors in vitro at sites that either activate or repress gene expression. Ca(2+)/calmodulin-dependent protein kinase IV (CaMKIV) is a monomeric, multifunctional serine/threonine protein kinase that is expressed in subanatomic regions of the central and peripheral nervous system, T lymphocytes, and male germ cells. It is frequently localized to the nucleus, where it serves as a mediator of Ca(2+)-dependent gene expression Inhibition of CAMKIV may be useful in the treatment of anxiety and stress-related disorders through decrease in corticoropin-releasing hormone (CRH), several cancers (e.g., small cell lung, hepatocellular, ovarian) and sperm motility. GenBank D30742

Target Class:

Kinase

Family:

CAMK

Sub Family:

Protein Ser/Thr

Protein Name:

CaMK4

Protein Aliases:

brain Ca++-calmodulin-dependent protein kinase type IV|calcium/calmodulin-dependent protein kinase type IV catalytic chain|CAM kinase IV|CAM kinase- GR

Accession Number:

NM_001744.3

UniProt Number:

Q16566

Gene Name:

CAMK4

Gene ID:

814

Gene Aliases:

CAMK|CAMK-GR|CAMKIV

Target Species:

Human