cAMP Hunter™ 1321N1 CALCR-RAMP3 Gs Cell Line

The cAMP Hunter™ 1321N1 CALCR-RAMP3 Gs Cell Line measures CALCR (GPCR) activity via increased levels of intracellular cAMP. This cell line ships as two vials of cryopreserved cells.

Catalog #: 95-0166C6 Size: 2 vials

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Biological Information
Background Information:	The cAMP Hunter™ CALCR-RAMP3 Gs cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. calcitonin) based activation of CALCR GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type CALCR , a naturally Gs coupled GPCR, alongside modulator protein RAMP3. Upon activation of CALCR-RAMP3 , the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. This product expresses CALCR alongside the receptor modifying protein RAMP3, which increases activity of the CALCR receptor
Target Class:	GPCR
Family:	Calcitonin Receptor
Sub Family:	Class B
Coupling:	Gs
Accession Number:	NM_001742.2
Target Name:	CALCR-RAMP3
Target Aliases:	Calcitonin receptor, CRT, CT-R, CTR, CTR1
Target Species:	Human
Cell Background:	1321N1

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	cAMP Detection
Detection Method:	Chemiluminescence

Additional Information
Brand:	cAMP Hunter™